The effect of pretreatment of HNECs with T16Ainh-A01, a specific inhibitor of TMEM16A, was investigated to determine if EGF-induced increase in MUC5AC expression was mediated by TMEM16A As shown in Fig. 3, pretreatment of the HNECs from CRSwNP patients with T16Ainh-A01 (10 μM) for 30 min before incubation with EGF 100 ng/ml significantly inhibited the EGF-induced increase in MUC5AC mRNA and

Objective: Primary cultured cochlear stria vascularis endothelial cells (ECs) of guinea pig were used to investigate the expression changes of TMEM16A and its

Cited in 8 publications. View and buy high purity T16Ainh - A01. Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Cited in 8 publications. T16Ainh-A01 relax rodent resistance arteries in a concentration dependent way, an equivalent vasorelaxation occurs in rodent arteries when the transmembrane chloride gradient is abolished with an impermeant anion), 23 this reduces the reliability of T16Ainh-A01's dependence on TMEM16A. T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).

- Mechanism of Action & Protocol. Background and Purpose T16Ainh‐A01 is a recently identified inhibitor of the calcium‐activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16Ainh‐A01 for inhibition T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+.

T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities

T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh - A01 Ca 2+ -activated Cl - channel transmembrane protein 16A (TMEM16A) inhibitor CAS# 552309-42-9 Catalog No. BCC6220 ----Order now to get a substantial discount! The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications.

Background and Purpose T16Ainh‐A01, CaCCinh‐A01 and MONNA are identified as selective inhibitors of the TMEM16A calcium‐activated chloride channel (CaCC). The aim of this study was to examine the c

The aim of this study was to test the efficacy of T16Ainh‐A01 for inhibition T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications.

Cited in 8 publications. CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2 T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).
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The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References: We then examined the effect of T16Ainh-A01, a TMEM16A inhibitor, on the increase in Cl ion transport. The tracheal epithelium was immunostained with an anti-TMEM16A antibody.

Utility Header Menu Right. 800-343-7475; Contact Us; Cart Chemical Formula: C19H20N4O3S2 Exact Mass: 416.0977 Molecular Weight: 416.514 Elemental Analysis: C, 54.79; H, 4.84; N, 13.45; O, 11.52; S, 15.39 Synonym: T16Ainh-A01 T16Ainh A01 T16AinhA01 T16A(inh)-A01 T16A(inh) A01 T16A(inh)A01 Chemical Name: 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide InChi Key: QSIYTNYMBWYHAA … T16Ainh - A01 Catalog No.GC17930: inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) Size Price Stock Qty; 5mg $30.00. In stock 10mg In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References: [1] Alison J Davis, et al.
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12 Feb 2019 These findings were inhibited by T16Ainh-A01 and confirm that TMEM16A plays a key role in persistent chronic constriction injury-induced

研究T16Ainh-A01（1-30μM）对由500nM游离Ca2+诱发的IC1Ca的作用。应用. 在兔肺动脉心肌细胞中，T16Ainh-A01（1-30μM）抑制由500nM游离Ca2+激活的全细胞电流。 References: [1] Alison J Davis, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01. Br J Pharmacol.

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We then examined the effect of T16Ainh-A01, a TMEM16A inhibitor, on the increase in Cl ion transport. The tracheal epithelium was immunostained with an anti-TMEM16A antibody. Epithelial cells from guinea-pig tracheas were cultured at the air-liquid interface in the presence of IL-13 for in vitro study.

The voltage-dependent component disappears due to VGCC inhibition, suggesting that Ca2+ is the essential trigger for ANO1. In perforated current-clamping method, the application of T16Ainh-A01 and reduction of T16Ainh-A01 is a selective inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). T16Ainh-A01 inhibits EGF-induced increases in CaCC currents, and blocks proliferation of pancreatic cancer and squamous carcinoma cells in culture. 研究T16Ainh-A01（1-30μM）对由500nM游离Ca2+诱发的IC1Ca的作用。应用.